Why does acute hemolytic transfusion reaction (AHTR) cause severe kidney damage, despite immediate cessation of the incompatible transfusion?

💡 Explanation

AHTR causes kidney damage due to the formation of antigen-antibody complexes, triggering inflammation and glomerular damage due to deposition; these complexes activate the complement system leading to direct cell lysis. Therefore, kidney damage occurs, rather than other organ failure, because the complexes are filtered and accumulate there.

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