Why does administering high insulin doses fail to restore normal glucose uptake in Type 2 Diabetes despite sufficient insulin receptors?

💡 Explanation

In Type 2 Diabetes, insulin resistance occurs because the downstream signaling pathway to GLUT4 is impaired, resulting in reduced GLUT4 translocation to the cell membrane despite insulin binding; therefore, glucose uptake remains low rather than receptor binding being directly blocked or glucagon overriding insulin's effects.

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