Which mechanism explains why an adjuvant improves vaccine effectiveness regarding immunological memory?

💡 Explanation

An adjuvant enhances the adaptive immune response by stimulating antigen-presenting cells and increasing the expression of costimulatory molecules on them, which enhances B cell activation and affinity maturation in germinal centers. Therefore, the vaccine leads to enhanced affinity maturation, rather than just antigen presentation, T cell signaling, or reduced T cell activity, because the adjuvant specifically amplifies the B cell response.

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