Why does blood pressure sometimes remain elevated in hypertension patients even after administration of ACE inhibitors?

💡 Explanation

ACE inhibitors block one angiotensin II production pathway, but alternative enzymatic pathways, such as chymase, can bypass ACE and generate angiotensin II independently. Because of this alternative production, blood pressure may remain elevated despite ACE inhibition; therefore, the continued presence of angiotensin II, rather than other mechanisms, explains the sustained hypertension.

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