Why does bone remodeling slow down significantly after prolonged immobilization in a plaster cast following a fracture?

💡 Explanation

Bone remodeling slows during immobilization because the reduced mechanical stress inhibits osteocytes, which normally stimulate bone formation and resorption through mechanotransduction; therefore, reduced load decreases bone turnover, rather than increased osteoblast activity or calcitonin's effects.

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