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Human Body & Health

Why does calcium oxalate, rather than calcium phosphate, primarily form kidney stones in individuals with hypocitraturia?

A)Oxalate is more easily filtered
B)Citrate normally inhibits oxalate crystallization
C)Phosphate solubility rises with pH
D)Hypercalciuria exclusively promotes oxalate

💡 Explanation

Citrate normally binds to calcium in the urine, inhibiting calcium oxalate crystallization. In hypocitraturia, less citrate is available, therefore calcium preferentially binds to oxalate, rather than phosphate, promoting calcium oxalate stone formation. Oxalate filtration rate is less relevant.

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