Why does chronic intense musculoskeletal pain from nerve damage persist despite taking NSAIDs?

💡 Explanation

Chronic neuropathic pain often bypasses typical prostaglandin-mediated inflammation because the primary mechanism involves direct nerve damage and altered pain processing pathways, rather than peripheral inflammation targeted by NSAIDs. Therefore, NSAIDs are ineffective, rather than influencing substance P release or directly altering descending modulation.

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