Why does follicle-stimulating hormone (FSH) remain elevated in females experiencing primary ovarian insufficiency (POI)?

💡 Explanation

In POI, the ovaries fail to produce adequate levels of inhibin, which normally provides negative feedback to the pituitary to suppress FSH secretion; because this feedback is absent, FSH levels remain high. Therefore, low inhibin causes elevated FSH, rather than direct pituitary malfunction.

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