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← Human Body & HealthWhy does increased extracellular potassium around a neuron cause hyperexcitability?
A)Reduced sodium channel inactivation rate
B)Increased chloride ion influx rate
C)Decreased potassium concentration gradient✓
D)Elevated intracellular sodium concentration
💡 Explanation
Increased extracellular potassium reduces the potassium concentration gradient across the neuronal membrane, which reduces potassium efflux. Because the resting membrane potential is more depolarized, the neuron is closer to the threshold for firing an action potential; therefore, hyperexcitability results, rather than hyperpolarization.
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