Why does insulin resistance increase the risk of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes?

💡 Explanation

Insulin resistance causes an increase in hepatic lipogenesis exceeding fatty acid oxidation in the liver, leading to triglyceride accumulation and NAFLD. This occurs because the liver compensates for peripheral insulin resistance by synthesizing more fatty acids. Therefore, hepatic lipogenesis exceeds oxidation, rather than decreased glucose uptake or lipolysis.

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