Why does maladaptive vasodilation occur during septic shock, compromising thermoregulation?

💡 Explanation

Septic shock causes widespread vasodilation due to excessive production of nitric oxide induced by inflammatory cytokines; because of this, blood pressure drops dangerously, leading to inadequate tissue perfusion and organ dysfunction. Therefore, vasodilation in septic shock is maladaptive rather than thermoregulatory, unlike normal responses to heat exposure.

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