Why does pancreatic enzyme activity sharply decrease as chyme enters the jejunum in a patient with untreated celiac disease?

💡 Explanation

In celiac disease, villous atrophy impairs secretin release in the duodenum, which normally stimulates pancreatic enzyme secretion. Because this stimulation is reduced, pancreatic enzyme activity decreases in the jejunum; therefore, impaired secretin release is the main reason, rather than altered vagal stimulation or direct inhibition.

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