Why does platelet aggregation following vascular injury primarily occur at the injury site, rather than systemically?

💡 Explanation

Platelet aggregation is localized because exposed collagen at the injury site binds to von Willebrand factor, which then binds to platelet receptors, initiating the aggregation cascade. Therefore, aggregation occurs locally, rather than systemically, because the initial trigger is localized to the injured vessel, rather than being a systemic signal.

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