Why does Roux-en-Y gastric bypass often reduce appetite more effectively than adjustable gastric banding, despite both restricting stomach volume?

💡 Explanation

Gastric bypass involves rerouting the digestive tract, leading to increased secretion of GLP-1, a hormone that promotes satiety. This enhances the signaling pathway for fullness, because the bypass causes nutrients to reach the lower intestine faster, therefore producing more GLP-1, rather than mere stomach volume restriction as with banding.

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