A patient consistently feels hungry shortly after consuming a carbohydrate-rich meal. Which mechanism explains why this individual experiences early satiety failure?

💡 Explanation

Following a meal, GLP-1 (glucagon-like peptide-1) is released from the gut to promote satiety. A blunted GLP-1 response impairs this satiety signaling because it fails to activate pathways in the brain that suppress appetite; therefore, the patient experiences early satiety failure, rather than enhanced leptin sensitivity or sustained ghrelin suppression.

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