Why does sustained hypocalcemia increase the risk of osteoporosis despite adequate calcium intake?

💡 Explanation

Hypocalcemia triggers increased parathyroid hormone (PTH) secretion. PTH stimulates osteoclast activity to liberate calcium from bone mineral into the blood, because this process is essential for nerve and muscle function. Therefore, chronic PTH elevation leads to net bone mineral loss, increasing osteoporosis risk rather than stimulating bone formation.

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