Why does targeted temperature management (TTM) after cardiac arrest sometimes paradoxically induce shivering despite the intent to cool the patient?

💡 Explanation

Shivering is a thermoregulatory response caused by a discrepancy between the actual body temperature and the hypothalamus's temperature setpoint. TTM can trigger the hypothalamus to reset the setpoint lower, but the body's actual temperature may still be perceived as 'too high', therefore triggering shivering, rather than preventing it.

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