Why does decreased Langerhans cell function increase skin cancer risk upon UV exposure?

💡 Explanation

Langerhans cells, as antigen-presenting cells, activate T-cells to target cancerous cells. Their dysfunction impairs this immune response, because proper antigen presentation is critical for initiating cytotoxic T-cell activity; therefore, cancer risk increases, rather than decreased melanin, collagen changes, or sebum levels being primary factors.

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