Why does the accumulation of misfolded amyloid beta proteins in the brain accelerate in late-stage Alzheimer's disease?

💡 Explanation

The accumulation accelerates because the autophagy-lysosome pathway, responsible for clearing misfolded proteins, becomes less efficient with age and disease progression. Therefore, amyloid beta clearance diminishes, rather than increasing chaperone activity or microglial phagocytosis, contributing to disease severity.

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