Why does trabecular bone volume decrease during extended immobilization?

💡 Explanation

Extended immobilization reduces mechanical stress on bone, and because Wolff's Law states bone remodels according to imposed stresses, osteoclast activity increases relative to osteoblast activity. Therefore, bone resorption surpasses bone formation, leading to decreased trabecular bone volume, rather than maintained osteoblast activity or improved nutrient delivery.

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