A cancer cell has a mutation causing constitutive activation of a growth factor receptor. If a drug inhibits a key protein in the apoptosis pathway, which consequence follows?

💡 Explanation

If apoptosis is inhibited, cancer cells are no longer signaled to self-destruct. Because the apoptotic signals are blocked, the cells continue dividing, therefore resistance to apoptosis increases, rather than triggering cell cycle arrest through DNA damage checkpoints.

• An individual with Type 2 diabetes displays sustained hyperglycemia despite increased insulin levels. Which signaling defect most likely explains this phenomenon?
• Why does hypertension commonly develop in elderly individuals with arteriosclerosis?
• An individual with a known bee sting allergy experiences anaphylaxis after being stung. Which mechanism explains why localized mast cell degranulation rapidly leads to systemic vasodilation and bronchoconstriction?
• During intense exercise, alveolar PO2 remains relatively stable despite increased ventilation and O2 consumption. Which mechanism explains why alveolar PO2 doesn't drop significantly?
• Why does long-term potentiation strengthen synaptic connections during sleep?
• Why does bariatric surgery often lead to remission of type 2 diabetes, especially considering the altered gut hormone signaling?