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Human Body & Health

A patient with cirrhosis experiences elevated blood ammonia levels. Which mechanism explains why hyperammonemia occurs in liver failure?

A)Increased urea cycle enzyme production
B)Impaired hepatic urea synthesis
C)Enhanced renal ammonia excretion
D)Accelerated glutamine synthesis in muscles

💡 Explanation

Hyperammonemia in liver failure happens because the liver's capacity for urea synthesis diminishes. The urea cycle, normally converting ammonia to urea, is impaired. Therefore, ammonia accumulates in the bloodstream rather than being processed, rather than being excreted efficiently.

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