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Human Body & Health

A patient with impaired neutrophil function sustains a deep dermal wound; which consequence affecting collagen synthesis most likely occurs?

A)Collagen production exceeds degradation
B)Elevated TGF-β1 stimulates fibrosis
C)Increased fibroblast differentiation occurs rapidly
D)Diminished collagen crosslinking delays repair

💡 Explanation

Neutrophils clear debris and pathogens, and without them, prolonged inflammation persists, leading to elevated matrix metalloproteinases (MMPs) that degrade newly synthesized collagen. Because MMP activity overwhelms collagen deposition, therefore diminished collagen crosslinking and delayed wound repair occur, rather than enhanced production or rapid differentiation seen in normal healing.

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