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Human Body & Health

If an athlete experiences intense muscle fatigue during a sprint due to sustained anaerobic glycolysis, which failure mode becomes most likely in the muscle fibers?

A)Increased calcium reuptake by SERCA
B)Elevated phosphocreatine buffering capacity
C)Enhanced oxidative phosphorylation efficiency
D)Inhibition of actin-myosin cross-bridge cycling

💡 Explanation

Sustained anaerobic glycolysis leads to lactate accumulation and decreased pH. This increased acidity inhibits actin-myosin cross-bridge cycling because it interferes with the binding affinity of calcium to troponin, therefore impairing muscle contraction, rather than enhancing performance.

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