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Human Body & Health

A woman experiences recurrent luteal phase defects despite normal ovulation timing and estrogen levels. Which hormonal consequence is most likely limiting implantation?

A)Elevated baseline GnRH secretion
B)Decreased uterine prostaglandin synthesis
C)Increased prolactin receptor sensitivity
D)Insufficient progesterone receptor activation

💡 Explanation

Successful implantation requires adequate progesterone signaling to prepare the endometrium. Luteal phase defect implies insufficient progesterone receptor activation, because even with normal progesterone levels, the receptors might not be responding. Therefore, D is correct, rather than the other options affecting different hormonal axes.

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