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← Human Body & HealthFollowing a benzene exposure incident in a chemical plant, a worker develops aplastic anemia. Which mechanism explains why red blood cell transfusions alone cannot fully resolve his fatigue?
A)Increased erythropoietin receptor downregulation
B)Bone marrow stem cell depletion✓
C)Autoimmune destruction of transfused cells
D)Iron overload from repeated transfusions
💡 Explanation
Aplastic anemia, in this case induced by benzene, leads to depletion of bone marrow stem cells, the source of all blood cells. Because the underlying problem is a lack of production rather than merely a loss of red blood cells, transfusions only temporarily alleviate the anemia; therefore, stem cell transplantation or immunosuppression are often necessary, rather than relying solely on transfusions.
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