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Human Body & Health

An individual receives multiple booster vaccinations against an evolving influenza strain. Which outcome directly reflects affinity maturation in memory B cells?

A)Decreased somatic hypermutation rate
B)Reduced antibody binding site diversity
C)Increased antibody-antigen binding strength
D)Slower class switching to IgG subtypes

💡 Explanation

Repeated exposure to slightly different antigens drives affinity maturation because B cells producing antibodies with higher affinity for the antigen are preferentially selected to differentiate into plasma cells. Therefore, a higher affinity results, rather than lower affinity due to alternative processes.

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