During acute inflammation, why does activated NF-κB contribute to inflammation resolution, despite initially promoting pro-inflammatory cytokine production?

💡 Explanation

NF-κB activation induces not only pro-inflammatory responses but also the expression of genes that promote resolution via lipoxins and resolvins. It does this because these lipid mediators actively terminate inflammation. Therefore, activating pro-resolution lipid synthesis explains NF-κB's role, rather than solely promoting apoptosis or inhibiting neutrophil chemotaxis.

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