During an epileptic seizure, inhibitory GABAergic neurons are overwhelmed, leading to excessive action potential firing in the brain. Which effect is most likely?

💡 Explanation

Increased action potential firing leads to more frequent depolarization of presynaptic terminals, which then causes increased calcium influx and subsequent glutamate release. Therefore, the correct answer is increased glutamate release rather than reduced resting membrane potential because this results from GABA agonists, which are overwhelmed during seizure activity.

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