Which effect results when a mutation disrupts the enzyme tetrahydrofolate reductase in the folate metabolic pathway?

💡 Explanation

Disruption of tetrahydrofolate reductase impairs the folate pathway because it catalyzes the reduction of dihydrofolate to tetrahydrofolate, a crucial cofactor for nucleotide synthesis. Therefore, DNA and RNA synthesis are impaired, rather than other cellular functions being directly affected by folate levels.

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