If a drug blocks the reuptake transporter for dopamine in the synapse of the nigrostriatal pathway, which consequence follows for dopamine signaling?

💡 Explanation

Blocking the reuptake transporter increases dopamine concentration and its duration of action in the synaptic cleft because dopamine remains available to bind to receptors for a longer period, therefore increasing postsynaptic signaling, rather than decreasing synthesis or directly affecting receptors.

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