Why does blocking prostaglandin E2 (PGE2) synthesis reduce fever during an infection?

💡 Explanation

Blocking PGE2 synthesis reduces fever because PGE2 acts on the hypothalamus to increase the body's temperature set-point. Therefore, reducing PGE2 allows the hypothalamus to return to its normal set-point, rather than affecting vasodilation or vasoconstriction directly.

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