If a drug rapidly distributes into tissues, resulting in a high volume of distribution and then the liver is compromised, which consequence follows regarding drug half-life?

💡 Explanation

A high volume of distribution means the drug is largely outside the plasma, reducing the amount presented to the liver for metabolism. Because liver compromise reduces drug clearance, and half-life is inversely proportional to clearance, the half-life increases. Therefore, the half-life significantly increases, rather than decreases or remaining unchanged, because reduced clearance prolongs the drug's presence in the body.

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