If a drug's clearance decreases due to kidney dysfunction, which consequence follows regarding its steady-state concentration, assuming the dosing rate remains constant?

💡 Explanation

An increased steady-state concentration results because drug clearance represents the rate of drug removal from the body. Reduced clearance means less drug is eliminated per unit time; therefore, more drug accumulates to reach steady state, rather than the concentration remaining unchanged or decreasing if clearance were normal.

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