If a patient has damaged osmoreceptors, leading to decreased sensitivity to plasma osmolality, which consequence is most likely regarding water balance regulation during dehydration?

💡 Explanation

Damaged osmoreceptors impair the ADH negative feedback loop, because the body fails to correctly sense high plasma osmolality. Reduced ADH secretion results in less water reabsorption in the collecting ducts of the kidneys; therefore, dehydration worsens, rather than improves, because the body is not signaled to conserve water.

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