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← Human Body & HealthIf a patient's inflammatory response is sustained due to persistent pathogen presence, which consequence concerning cytokine feedback becomes most likely?
A)Shift toward Th1 dominance reverses
B)Positive feedback amplifies inflammation✓
C)Neutrophil recruitment rate decreases
D)Macrophage polarization diminishes
💡 Explanation
Cytokine release stimulates further cytokine production via positive feedback loops involving transcription factors like NF-kB. Because persistent pathogens continually trigger cytokine release, these positive feedback loops amplify inflammation, causing tissue damage; therefore, option B is most likely, rather than a reduction in inflammatory responses.
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