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Human Body & Health

If a patient's inflammatory response is sustained due to persistent pathogen presence, which consequence concerning cytokine feedback becomes most likely?

A)Shift toward Th1 dominance reverses
B)Positive feedback amplifies inflammation
C)Neutrophil recruitment rate decreases
D)Macrophage polarization diminishes

💡 Explanation

Cytokine release stimulates further cytokine production via positive feedback loops involving transcription factors like NF-kB. Because persistent pathogens continually trigger cytokine release, these positive feedback loops amplify inflammation, causing tissue damage; therefore, option B is most likely, rather than a reduction in inflammatory responses.

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