If a patient undergoes allergen immunotherapy involving gradually increased exposure, which consequence follows regarding subsequent allergic reactions?

💡 Explanation

Allergen immunotherapy aims to desensitize the patient via repeated allergen exposure, which induces a shift from IgE to IgG4 antibody production, because IgG4 competes with IgE for allergen binding, thereby reducing mast cell degranulation and histamine release. Therefore, mast cell degranulation is reduced, rather than enhanced, histamine sensitivity or increased anaphylaxis risk.

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