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Human Body & Health

If antibiotic concentration fluctuates below the minimum inhibitory concentration within a biofilm due to irregular dosage, which consequence follows?

A)Increased biofilm matrix degradation
B)Decreased bacterial metabolic activity
C)Suppressed efflux pump expression
D)Selection for antibiotic-resistant mutants

💡 Explanation

Sub-inhibitory antibiotic concentrations selectively favor resistant strains, because susceptible bacteria are killed while resistant ones survive and proliferate via natural selection. Therefore, antibiotic resistance emerges, rather than biofilm breakdown or metabolic suppression, that require different conditions.

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