If a patient with a history of autoimmune disease receives a bone marrow transplant from a healthy donor, why does graft-versus-host disease (GVHD) often develop despite immunosuppressive therapy?

💡 Explanation

GVHD occurs because donor T-cells in the transplanted bone marrow recognize the recipient's tissues as foreign, initiating an immune response; therefore, the donor T-cells attack recipient cells, rather than the recipient's immune system attacking the graft despite immunosuppression.

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