If a patient with diabetes insipidus, characterized by insufficient ADH release, is given a synthetic ADH analog, desmopressin, which consequence affecting the collecting ducts follows?

💡 Explanation

Desmopressin binds to V2 receptors in the collecting ducts, stimulating aquaporin-2 insertion, which increases water reabsorption. Because diabetes insipidus results in reduced ADH, this action of desmopressin corrects the water balance, therefore increasing water reabsorption, rather than sodium excretion or reduced urea transport.

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