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Life Sciences & Medicine

If a pharmaceutical company aims to increase cAMP levels within a cell to treat asthma, which consequence follows an activation of adenylyl cyclase?

A)Decreased protein kinase A (PKA) activity
B)Increased protein kinase A (PKA) activity
C)Reduced glycogen breakdown rate
D)Increased glycogen synthase activity

💡 Explanation

Increased cAMP levels activate protein kinase A (PKA) because cAMP directly binds to the regulatory subunits of PKA, releasing the catalytic subunits to phosphorylate downstream targets. Therefore, increased adenylyl cyclase activity leads to increased PKA activity, rather than decreased activity or impacting glycogen metabolism directly.

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