If an individual with iodine deficiency develops increased thyroid-stimulating hormone (TSH) levels, which compensatory change is least likely?

💡 Explanation

With iodine deficiency, the thyroid cannot produce sufficient T4. Enhanced peripheral deiodinase activity, which converts T4 to T3, would further deplete T4 reserves, providing little benefit to the thyroid. Therefore, deiodinase activity is unlikely to be enhanced, because this exacerbates the T4 shortage rather than compensating like increased NIS activity or thyroglobulin synthesis would.

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