If an overweight patient exhibits increased levels of serum insulin, yet persistently elevated blood glucose, which mechanism explains why GLUT4 translocation is impaired in their skeletal muscle cells?

A)Increased glycogen synthase activity

B)Elevated glucagon receptor expression

C)Downregulation of insulin receptor signaling✓

D)Increased hepatic gluconeogenesis sensitivity

💡 Explanation

Insulin resistance develops because prolonged exposure to high insulin levels causes downregulation of insulin receptor signaling pathways in muscle cells, hindering GLUT4 translocation. Therefore, glucose uptake is reduced, rather than increased glucose synthesis or glucagon action being responsible.

🏆 Up to £1,000 monthly prize pool

Ready for the live challenge? Join the next global round now.
*Terms apply. Skill-based competition.

⚡ Enter Arena

If an overweight patient exhibits increased levels of serum insulin, yet persistently elevated blood glucose, which mechanism explains why GLUT4 translocation is impaired in their skeletal muscle cells?

💡 Explanation

Related Questions