Why does stored blood exhibit decreased oxygen delivery to tissues compared to fresh blood transfusions?

💡 Explanation

Stored blood loses 2,3-BPG, decreasing hemoglobin's affinity for oxygen; this limits oxygen release to tissues because 2,3-BPG normally stabilizes the T-state of hemoglobin. Therefore, oxygen delivery is impaired, rather than enhanced by glycolysis or hemoglobin denaturation.

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