If chronic opioid use abruptly stops, which outcome arises from upregulated cAMP production in neurons of the nucleus accumbens during withdrawal?

💡 Explanation

Withdrawal symptoms occur due to cellular adaptations that counteract the drug's effects. Because opioids suppress cAMP production, chronic use causes compensatory upregulation. Therefore, during withdrawal, the now-elevated cAMP causes neuronal hyperexcitability, leading to anxiety and hyperalgesia, rather than reduced sensitivity or suppressed stress responses.

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