In a patient with chronic kidney disease (CKD) experiencing persistent hyperoxaluria despite dietary changes, which consequence follows from impaired tubular secretion of oxalate?

💡 Explanation

Impaired tubular secretion of oxalate in CKD means that oxalate remains in the filtrate, leading to supersaturation of calcium oxalate. This enhanced concentration encourages crystal formation, because the solubility product is exceeded, therefore promoting kidney stone development, rather than decreased solubility or hormonal changes.

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