In a patient with type 2 diabetes, if insulin levels are chronically elevated, which consequence becomes more likely at the cellular level in peripheral tissues?

💡 Explanation

Chronically elevated insulin levels in type 2 diabetes can lead to downregulation of insulin receptor expression because cells reduce their sensitivity to the hormone to prevent overstimulation; this is receptor desensitization. Therefore, insulin signaling diminishes, rather than enhances, GLUT4 translocation or glycogen synthesis.

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