Why does antibiotic resistance in Pseudomonas aeruginosa biofilms often persist despite treatment?

💡 Explanation

Antibiotic resistance persists in Pseudomonas aeruginosa biofilms because of efflux pumps which actively transport antibiotics out of the bacterial cells, thus reducing intracellular drug concentration. Therefore, the bacteria survive treatment, rather than due to slowed mutation or prevented drug penetration by the capsule.

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