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← Human Body & HealthWhy does excessive skin cleansing with harsh detergents frequently lead to increased acne outbreaks, even though the initial goal is to reduce sebum?
A)Disrupts epidermal growth factor signaling
B)Depletes skin's vitamin D production
C)Triggers reactive sebum overproduction✓
D)Induces keratinocyte apoptosis directly
💡 Explanation
Excessive cleansing removes sebum, disrupting the skin's natural barrier. This causes the sebaceous glands to undergo reactive seborrheogenesis, increasing sebum production to compensate for the loss, and therefore worsening acne, rather than reducing it, because sebum supports *C. acnes* growth.
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