Why does hyperthermia cause neurological damage faster than hypothermia, given equivalent deviations from the hypothalamic set point?

💡 Explanation

Hyperthermia accelerates metabolic rate beyond the brain's oxygen delivery capacity, leading to rapid cellular damage due to hypoxia. This occurs because enzymatic reaction rates increase exponentially with temperature. Therefore, neurological damage appears faster in hyperthermia rather than hypothermia, where slowed metabolism reduces oxygen demand.

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